Full Time Equivalent Program (FTE)
MBO has high capability to support the progression of Medicinal Chemistry services or Programs by managing a group of FTE's with additional cost effective offerings..!
Define a new synthetic approach that will allow access to novel synthesis on analogues or intermediates. MBO has Well balanced IP protection with economics from mgs to multi-gms scale.
Proof-of-concept (POC) elucidation of synthetic routes suitable for scale-up. Building blocks, scaffolds, and Reaction intermediate up to gms or more scale. Improve known synthetic sequences to access compounds of interest (enabling SAR). Natural products libraries and synthetic chemistry on gm scale to support API routes.
Larger, fragment-based libraries for downstream lead optimizations up to 100s of gms. Rapid screening of reaction conditions by utilizing parallel equipment.
Structural chemical class of compounds novelty assessment. Our synthetic chemistry teams are supported by experienced analytical and purification specialists.
Supports on route optimization and initial scale-up of potential development candidates. These scale-up activities are critical to support the transition between late discovery and early development.
MBO advantages on FTE-based proposals are outlined below..!
Judicious use of smaller amounts of material as per product value (mgs up to 100 gms).
Judicious use of smaller amounts of material as per product value (mgs up to 100 gms).
FTE projects can be done with one-offs and/or scaling of catalog items.
Project management is fully integrated ensuring maximum per FTE value, on mgs scale up to kgs.
Assigning internal resources to support the sourcing of scale-up activities can be time-consuming and burdensome.
MBO relieves the strain and drives client productivity. Through a strong partnership with a professional sourcing service, MBO offers rapid assessment of the cost and availability of reagents.
Fee-for-service program (FFS)
MBO is a leading contract research organization in India and provides innovative drug discovery services to the global pharmaceutical industry through Our R&D Center in the FFS model for short programs.
FFS collaborations are often the preferred route for smaller projects. Because FFS projects, by their nature, are more defined and less flexible than FTE relationships.
MBO research services meet the highest standards of professional performance to satisfy the unique requirements of our clients.
MBO team supports both integrated pre-clinical discovery programs and fixed-fees-for-services (FFS) projects and delivers quality and reproducible results with a quick turnaround time.
FFS projects involve synthetic procedure optimization, support for scale-up (up to Kilogram), purification techniques, Analytical Support etc. Moreover, MBO is open to discussing the pricing structure and is flexible to meet the needs of its clients.
Library Synthesis
MBO is able to support the progression of Library synthesis:
Quick access to quality compound libraries is the key driver to accelerating drug discovery, MBO has both components required to offer efficient service:
Parallel synthesis capabilities: Over 20-25 compounds are produced per day typically in 5-10 mg
This unique and powerful combination allows us to synthesize compound libraries within a short period of time.
Scaffold Services
MBO is able to support the progression of Scaffold synthesis:
Scaffolds Drug delivery are smart alternatives to conventional formulations and allow for controlled comprehensive releases of active compounds.
Proof-of-concept (POC) elucidation of synthetic routes suitable for scale-up. Building blocks, scaffolds, and intermediate up to gram or large scale.
Improve known synthetic sequences to access compounds of interest (enabling SAR).
Natural products libraries and synthetic chemistry on gm scale to support API .
MBO relieves the strain and drives client productivity. Through a strong partnership with a professional sourcing Service, MBO offers rapid assessment of the cost and availability of reagents.
Heterocyclic Compounds
MBO is able to support the progression of Heterocyclic Compounds
Heterocyclic Chemistry is interpreted in its broadest sense and we are the interest group closest to mainstream synthetic organic chemistry.
The following themes have been prevalent in recent years:
Synthesis and reactivity of heterocyclic compounds including mechanistic studies.
Practical applications of heterocyclic Compounds.
Total synthesis.
Heterocyclic intermediates and reagents.
New chemical entity
MBO to promote innovation and the development of new medicinal products
Make use of the fee incentives for scientific advice.
Drug substance synthesis is robust and well controlled.
Starting materials are adequately defined.
Potential impurities have been identified and have been accurately determined.
The quality of the drug substance is maintained throughout clinical development.
The commercial formulation of the drug product is optimized, can be reproducibly manufactured to the intended quality and is stable.
The results of pivotal clinical studies can be linked to the commercial formulation through appropriate bridging studies.
Refer to specific EU guidelines for products intended for marketing in EU.
Carbohydrate chemistry services
MBO is a dedicated of experience in the field of carbohydrate molecules, MBO has gained specialized expertise in complex oligosaccharides.
MBO carbohydrate portfolio includes multi-kg manufacturing of innovative carbohydrate products for monosaccharide building blocks.
MBO complex carbohydrate know-how has been successfully demonstrated on "several multi-kg cGMP manufacturing scales, delivering very high quality products" showing lot-to-lot consistency, with processes developed according to "Quality by Design (QbD)" and a manufacturing approach supported by Process Analytical Technology (PAT).
Unique back integration of non-GMP raw materials from "MBO sister company supports your carbohydrates projects with low cost targets."
Synthesis & manufacturing of complex & conjugated carbohydrates.
Preparative HPLC columns (10 cm – 100 cm ID).
Complex multi-step carbohydrates involving linear and convergent synthesis.
Monosaccharides.
Chiral molecule services
MBO scientists are proficiently in various methodologies used for synthesizing compounds and separating enantiomers with the required therapeutic activity from a racemic compound.
Asymmetric catalysis, chiral auxiliary and organo-catalysis are some of the asymmetric transformation methods that we use to explore new molecules.
MBO is a rapidly screen and identify single-enantiomer drug candidates for further testing.
Support small –molecules drug discovery with stationery phases that isolate pure enantiomers effectively and efficiently.
Protect your timeline by accelerating the selection of the optimal chiral column for your project.
Improve analytical procedures with new methods that provide faster and more efficient analyses.